Mebendazole (Vermox) : drug card
Drug name | # Mebendazole. |
Brand name | # Vermox. |
Class of drug | # Anthelmintic. |
Indications | # Anthelmintic (Pinworms, Roundworms, hookworms, whipworms). # Capillariasis. |
Mechanism of action | # Inhibits uptake of glucose and other nutrients by parasitic helminths. |
route / Dosage form | # Route : Oral only. # Dosage form : Sus:- 20mg/ml,Tab:- 100mg. |
Dose | # Pinworms * Adults, children >12 years: 100 mg as single dose. Repeat in 2 weeks if infection persists. Treat other family members. # Roundworms, hookworms, whipworms * 100 mg b.i.d. for 3 days. Repeat dose in 3–4 weeks. # Capillariasis * Pediatric: 200 mg b.i.d. for 20 days. Its use in children <2 years is considered a relative contraindication. |
Pregnancy / Lactation | # Pregnancy: Category C. # Lactation: Probably present in minute amounts in breast milk. May continue breastfeeding. |
Adverse reactions | # Common: diarrhea, abdominal pain, nausea, vomiting. # Serious: bone marrow suppression, hepatitis, hypersensitivity reactions. |
Important interactions | # Drugs that decrease effects/ toxicity of mebendazole: phenytoin, carbamazepine, cimetidine. |
Contraindications / precautions | # Use with caution in patients with liver disease, ulcerative colitis, Crohn’s ileitis. |
Other notes | # Food: Take with food. |
Practical notes | # Avoid driving and other activities requiring mental alertness or that are potentially dangerous until response to drug is known. # Patient and family members should shower frequently if possible. # Keep hands away from mouth. # Keep fingernails short and clean. # Do not shake bedding as this could result in airborne spread of ova. # Counsel patient’s family members to check for worm infestation and treat accordingly. # Disinfect toilet daily; wash all fruits and vegetables; cook all meats and vegetables thoroughly. # Wear gloves when preparing food. # Patient and family members should be taught how to avoid reinfestation with these worms. The following measures should be undertaken to avoid reinfection: (1) perianal area should be washed thoroughly; (2) hands and fingernails should be cleaned before meals and after defecation; (3) undergarments and bedclothes should be changed daily. # Mebendazole is the drug of choice for whipworm; it can produce up to 70% cure with a single treatment. The cure rate for roundworms, pinworms, and hookworms is 90–100%. The criterion for cure is negative perianal swabs for 7 days. # For those treated for hookworm and whipworm: it may be necessary to take an iron supplement every day and for 6 months following treatment if anemia is present. |
Generic names | # Egypt :Antiver,Vermin,Anthelmin,Mebamox,Verm1. # KSA :- Vermox,Bendazole,Parazole,wormazole. |
# prepared by : Dr.Mohamed Abd Elrahman
# References: - Handbook of clinical drug data, 10th edition. - Clinician'shandbook of prescription drugs . - Physicians' Drug Manual 2005 Edition . -Egyptian drug index . - Saudi drug index .
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