Lectures

Antibiotics course.1-Quinolones : lecture

Contents :-Quinolones and fluoroquinolones.Other quinolones.Basic structure of the quinolones.Mechanism of action.Spectrum of fluroquinolon...

10 Dec 2010 / 0 Comments / Read More »
Notes

Hyperparathyroidism : note

• Hyperparathyroidism results from anincrease in the secretion of PTH (parathyroid hormon)• The most common cause (80% of thecases) is a be...

06 Dec 2010 / 0 Comments / Read More »

Cystic fibrosis : note

• Patients with cystic fibrosissecrete very viscous mucus in the lung andsuffer repeated lung infections.The pancreas is also affected and ...

05 Dec 2010 / 0 Comments / Read More »

Obstructive lung disease : note

• Lung volumes are changeddifferently by restrictive and obstructive disease.• Obstructive lung disease iscommonly associated with smoking ...

01 Dec 2010 / 1 Comments / Read More »

General anesthetic drugs : note

# General anesthetic drugs are :-Inhaled :-  * Halothane.   * Isoflurane.  * Nitrous oxide.Intravenous :-   *...

16 Oct 2010 / 0 Comments / Read More »

Videos

  • How to use a peak flow meter : video

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  • The use and the action of Epipen : video

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  • Understanding of enzymes work : video

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  • Understanding of osmosis : video

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  • Exocitosis and endocitosis through cell membrane : video

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  • The structure of DNA : video

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  • The structure of chromosome : video

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  • Understanding of DNA replication process : video

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  • Understanding of meiosis process : video

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  • Understanding of active transport and Na/K pump : video

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Antibiotics course.1-Quinolones : lecture

Contents :-Quinolones and fluoroquinolones.Other quinolones.Basic structure of the quinolones.Mechanism of action.Spectrum of fluroquinolon...

10 Dec 2010 / 0 Comments / Read More »

Mebendazole (Vermox) : drug card

Drug name # Mebendazole. Brand name # Vermox. Class of drug # Anthelmintic. Indications # Anthelmintic (Pinworms, Roundworms...

07 Dec 2010 / 0 Comments / Read More »

Hepatitis A (HAV): Rapid review

·       Introduction. ·       Signs and symptoms....

28 Dec 2010 / 1 Comments / Read More »

The anatomy of the skeletal muscles : video

* How does skeletal muscle attach to bones ?* What are the parts of the skeletal muscle ?* How does the skeletal m...

18 Jul 2010 / 0 Comments / Read More »

Antibiotics course.1-Quinolones : lecture

Contents :-Quinolones and fluoroquinolones.Other quinolones.Basic structure of the quinolones.Mechanism of action.Spectrum of fluroquinolon...

10 Dec 2010 / 0 Comments / Read More »

Rapid Reviews

Hepatitis A (HAV): Rapid review

·       Introduction. ·       Signs and symptoms....

28 Dec 2010 / 1 Comments / Read More »

The use of muscle relaxants in surgical procedures : rapid review

# introduction* Acetylcholine is a major neurotransmitter in the autonomic nervous system. In the peripheral nervous system, acetylcholine ...

14 Jul 2010 / 0 Comments / Read More »

Gallstones : rapid review

# How are the gallstones formed :-* Bile help the body to digest fat , it is made in the liver , stored in the gallbladder until the body n...

24 Jun 2010 / 0 Comments / Read More »

Lipid lowering agents : rapid review

Preface   Triglycerides:     * main constituent of vegetable oil & animal fat .    * High ...

10 Jun 2010 / 0 Comments / Read More »

Drug cards

Mebendazole (Vermox) : drug card

Drug name # Mebendazole. Brand name # Vermox. Class of drug # Anthelmintic. Indications # Anthelmintic (Pinworms, Roundworms...

07 Dec 2010 / 0 Comments / Read More »

Acyclovir (Zovirax) : drug card

Drug name # Acyclovir. Brand name # Zovirax. Class of drug # Antiviral agent. Indications # Herpes simplex (HSV-1 and HSV-2) ...

11 Oct 2010 / 3 Comments / Read More »

Acetylcysteine ( mucomyst ) : drug card

Drug name # Acetylcysteine. Brand name # Mucomyst. Class of drug # Mucolytic agent.     # antidote. Indi...

04 Oct 2010 / 0 Comments / Read More »

Featured

  • Antibiotics course.1-Quinolones : lecture

    Contents :-Quinolones and fluoroquinolones.Other quinolones.Basic structure of the quinolones.Mechanism of action.Spectrum of fluroquinolon...

  • Mebendazole (Vermox) : drug card

    Drug name # Mebendazole. Brand name # Vermox. Class of drug # Anthelmintic. Indications # Anthelmintic (Pinworms, Roundworms...

  • Acyclovir (Zovirax) : drug card

    Drug name # Acyclovir. Brand name # Zovirax. Class of drug # Antiviral agent. Indications # Herpes simplex (HSV-1 and HSV-2) ...

  • The use of muscle relaxants in surgical procedures : rapid review

    # introduction* Acetylcholine is a major neurotransmitter in the autonomic nervous system. In the peripheral nervous system, acetylcholine ...

1:22 PM | Posted by Unknown

Acetylcysteine ( mucomyst ) : drug card


Drug name
# Acetylcysteine.
Brand name
# Mucomyst.
Class of drug
# Mucolytic agent.     # antidote.
Indications
# Mucolytic agent in Bronchial disorders, chronic bronchitis, asthma, emphysema, pulmonary complications of surgery.
# Antidote for acetaminophen poisoning. 
Mechanism of action
# As mucolytic agent: disrupts disulfide bonds in mucoproteins thereby lowering viscosity of mucus.

# As antidote for acetaminophen poisoning: complexes with hepatotoxic free radial metabolite of acetaminophen and inactivates it.
route / Dosage form
# Route : Oral, inhalation, IV.
# Dosage form : Soln: 10, 20%
Dose
# Bronchial disorders, chronic bronchitis, asthma, emphysema, pulmonary complications of surgery :-
* Adults: 6–10 mL of 10% solution, q2–3 hours by nebulizer.
* Children: 3–5 mL of 10% solution, q2–3 hours by nebulizer.
* Infants: 2–4 mL of 10% solution, t.i.d. to q.i.d., IV.
* Alternate: 20% solution may be given in half of above volumes.

# Antidote for acetaminophen poisoning
* Adults, children: Initially 140 mg/kg, then 70 mg/kg q4h orally x 17 doses. All 17 doses must be given, even if acetaminophen   levels have declined to non-toxic range. If patient has emesis with 1 hour of dose, repeat dose immediately.
Pregnancy / Lactation
# Pregnancy: Category B.
# Lactation: No data available. Best to avoid.
Adverse reactions
# Common: vomiting, olfactory disturbance.
# Serious: bronchospasm (especially in asthmatics), hypotension.
Important interactions
# None
Contraindications / precautions
# As inhaled drug: may induce bronchospasm. If this occurs, administer bronchodilator; suction bronchial secretions if they develop after inhalation.
# Elderly: May have reduced cough reflex and therefore reduced ability to clear airway of liquefied mucus. May need concomitant suction.
# For patient with asthma or hyperactive airway disease, a bronchodilator should be administered before acetylcysteine.
Other notes
# To be given before meals and just before bedtime for asthma.
# As antidote for acetaminophen poisoning: Administer as quickly as possible. Most useful if given within 12 hours of ingestion of acetaminophen.
Practical notes
# Rinse mouth out and wash face after treatment to remove adhering drug.
Generic names
# Egypt :- Acetylcistein , ACC , Mucomyst .
# KSA :- ------

# prepared by : Dr.Mohamed Abd Elrahman
# References:  - Handbook of clinical drug data, 10th edition. - Clinician's handbook of prescription drugs . - Physicians' Drug Manual 2005 Edition . - Egyptian drug index . - Saudi drug index .
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