10:33 AM | Posted by Unknown

Acyclovir (Zovirax) : drug card

Drug name	# Acyclovir.
Brand name	# Zovirax.
Class of drug	# Antiviral agent.
Indications	# Herpes simplex (HSV-1 and HSV-2) infections and immune-compromised host. # Genital herpes infections. # Herpes simplex encephalitis. # Herpes zoster infections. # Chickenpox infections.
Mechanism of action	# Nucleotide analog; inhibits viral replication by termination of viral DNA chain and inhibition and inactivation of viral DNA polymerase.
route / Dosage form	# Route : Oral, IV, Topical. # Dosage form : Cap 200; Tab 400, 800 mg; Inj 500 mg, 1 g; Inj 50 mg/mL; Oint 5%; Susp 40 mg/mL
Dose	# Herpes simplex (HSV-1 and HSV-2) infections (immunocompromised host) * Adults, children >12 years: IV 5 mg/kg (infuse at constant rate over 1 hour), q8h for 7 days. * Children <12 years: IV 250 mg/m2 (infuse at constant rate for 1 hour), q8h. # Genital herpes * Adults, children >12 years: PO 200 mg q4h, five doses/day; 10 days for initial therapy. Dose for 5 days for intermittent recurrent disease. Administer up to 12 months for chronic disease (suppressive therapy). * Children <12 years: IV 250 mg/m2, t.i.d. for 10 days. # Herpes simplex encephalitis * Adults, children >12 years: IV 10 mg/kg (infuse at constant rate over 1 hour), q8h for 10 days. * Children, 6 months to 12 years: IV 500 mg/m2 (infuse at constant rate over 1 hour), q8h for 10 days. # Herpes zoster * Adults, children >12 years: PO 80 mg, q4h, five doses/day, 7–10 days. * Children <12 years: PO 250–600 mg/m2, 4–5 times/day, 7–10 days. # Chickenpox * Adults, children >40 kg: PO 800 mg, q.i.d. 5 days. * Children >2 years: PO 20 mg/kg q.i.d. (maximum 800 mg), 5 days.
Pregnancy / Lactation	# Pregnancy: Category C. # Lactation: Appears in breast milk.
Adverse reactions	# Common: headache, phlebitis (IV only). # Serious: seizures, renal failure, anaphylaxis, encephalopathy (confusion, hallucinations), coma, leukopenia, renal crystalline precipitant, elevated liver enzymes, Stevens–Johnson syndrome, urticaria.
Important interactions	# Drugs that increase effects/toxicity of acyclovir: MAO inhibitors, probenecid, ziduvine, CNS depressants. # Drugs that decrease effects/toxicity of acyclovir: β blockers, guanethidine.
Contraindications / precautions	# Use with caution in patients with the following conditions: kidney disease, neurologic disease. # Beware of renal dysfunction especially if patient is taking other nephrotoxic drugs. # Women with genital herpes should have annual Pap smears. # Rapid bolus administration may cause crystalline precipitation in renal tubules and renal insufficiency. # Patients receiving acyclovir IV must remain well hydrated during treatment and for 24 hours after treatment. # Cases of thrombotic thrombocytopenic purpura/hemolytic uremia syndrome have been reported with high-dose acyclovir in immunocompromised patients.
Other notes	# Kidney disease: dose should be adjusted according to creatinine clearance. # Pediatric: Safety has not been established in children <2 years old.
Practical notes	# Drink 2–3 L of fluid per day. This is particularly important following IV infusion. # Avoid sexual intercourse when lesions are present; otherwise use condoms. # Avoid contact of the drug with or around the eyes. # Resume treatment at first indication of recurrence of infection. # Use a finger cot or latex glove when applying acyclovir ointment. The ointment might cause transient burning or stinging.
Trade names	# Egypt :- Zovirax, Acyclovir, Virustat, Novirus, Lovir, Cycloviral. # KSA :- Zovirax, Virustat, Acyclovir, Acivir, Clovir, Custiviral, Deforax, Herpavir, Imavir, Lovrak, Medvirox, Noviral, Novirax, ,

# prepared by : Dr.Mohamed Abd Elrahman

# References: - Handbook of clinical drug data, 10th edition. - Clinician'shandbook of prescription drugs . - Physicians' Drug Manual 2005 Edition . -Egyptian drug index . - Saudi drug index .

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Posted by Unknown on 10:33 AM. Filed under drug cards, drugs, featured, microbiology, virology . You can subscribe to the site updates through the RSS 2.0 or by Email

3 comments for "Acyclovir (Zovirax) : drug card"

TRISHA NELSON
July 9, 2020 at 3:34 AM

HELLO EVERYONE.. FEW MINUTES TO READY THIS INFO ON HERPES CURE.
MY MOTHER WAS DIAGNOSED OF HERPES/ KNOWN AS GENITAL WARTS ,I SPENT A LOT OF MONEY ON HER MEDICATION TILL A POINT I EVEN LOST HOPE,BECAUSE MY MOTHER WAS GRADUALLY DYING AND LOST HER MEMORY TOO, I WAS SO DESPERATE TO GET MY MOTHER BACK TO NORMAL, ONE DAY MY UNCLE WHO LIVES IN LONDON UNITED KINGDOM TOLD ME ABOUT DR JAMES ,WHO HELPED HIM GET RID OF HERPES /GENITAL WART WITH HERBAL MEDICINE AND HIS HERBAL SOAP ,I WAS SO SHOCKED WHEN HE TOLD ME ABOUT THIS ,ALTHOUGH I NEVER BELIEVE IN HERB BUT, I KEEP TO BELIEVE BECAUSE MY UNCLE CAN'T TELL ME LIES WHEN IT COMES TO HEALTH CONDITION I CONTACTED DR JAMES VIA HIS EMAIL; DRJAMESHERBALMIX@GMAIL.COM , YOU CAN TALK TO HIM VIA CALL OR WHATSAPP MESSENGER ON +2348152855846 , HE REPLIED AND ASK ME TO SEND MY HOME ADDRESS AND MY MOTHER'S DETAIL AND THEN I PURCHASED THE HERBAL MEDICINE,SENT ME THE HERBAL MEDICINE THROUGH COURIER SERVICE, WHEN I RECEIVED THIS HERBAL MEDICINE USED IT FOR 2 WEEKS, AND 4 DAYS OF USAGE THE WARTS FELL OFF, MY MOTHER I NOW TOTALLY CURED AND MY MOTHER IS LIVING FREE AND HAPPY AGAIN. YOU CAN TALK TO DR VIA HIS MOBILE NUMBER OR WHATS APP HIM ON if you have any of these diseases lupus disease, mouth ulcer, mouth cancer, body pain, fever, hepatitis ABC, syphilis, diarrhea, HIV / AIDS, Huntington's disease, back acne, chronic kidney failure, addison's disease, chronic pain, Crohn's pain, cystic fibrosis, fibromyalgia, inflammatory Bowel disease, fungal nail disease, Lyme disease, Celiac disease, Lymphoma, Major depression, Malignant melanoma, Mania, Melorheostosis, Meniere's disease, Mucopolysaccharidosis, Multiple sclerosis, Muscular dystrophy, Rheumatoid arthritis Alzheimer's disease, parkinson's disease, vaginal cancer, epilepsy Anxiety Disorders, Autoimmune Disease, Back Pain, Back Sprain, Bipolar Disorder, Brain Tumor, Malignant, Bruxism, Bulimia, Cervical Disc Disease, Cardiovascular Disease, Neoplasms , chronic respiratory disease, mental and behavioral disorder, Cystic Fibrosis, Hypertension, Diabetes, Asthma, Inflammatory Media autoimmune arthritis ed. chronic kidney disease, inflammatory joint disease, impotence, alcohol spectrum feta, dysthymic disorder, eczema, tuberculosis, chronic fatigue syndrome, constipation, inflammatory bowel disease. and many more; +2348152855846.ALL THANKS TO DOCTOR DR JAMES
TRISHA NELSON
July 9, 2020 at 3:35 AM

HELLO EVERYONE.. FEW MINUTES TO READY THIS INFO ON HERPES CURE.
MY MOTHER WAS DIAGNOSED OF HERPES/ KNOWN AS GENITAL WARTS ,I SPENT A LOT OF MONEY ON HER MEDICATION TILL A POINT I EVEN LOST HOPE,BECAUSE MY MOTHER WAS GRADUALLY DYING AND LOST HER MEMORY TOO, I WAS SO DESPERATE TO GET MY MOTHER BACK TO NORMAL, ONE DAY MY UNCLE WHO LIVES IN LONDON UNITED KINGDOM TOLD ME ABOUT DR JAMES ,WHO HELPED HIM GET RID OF HERPES /GENITAL WART WITH HERBAL MEDICINE AND HIS HERBAL SOAP ,I WAS SO SHOCKED WHEN HE TOLD ME ABOUT THIS ,ALTHOUGH I NEVER BELIEVE IN HERB BUT, I KEEP TO BELIEVE BECAUSE MY UNCLE CAN'T TELL ME LIES WHEN IT COMES TO HEALTH CONDITION I CONTACTED DR JAMES VIA HIS EMAIL; DRJAMESHERBALMIX@GMAIL.COM , YOU CAN TALK TO HIM VIA CALL OR WHATSAPP MESSENGER ON +2348152855846 , HE REPLIED AND ASK ME TO SEND MY HOME ADDRESS AND MY MOTHER'S DETAIL AND THEN I PURCHASED THE HERBAL MEDICINE,SENT ME THE HERBAL MEDICINE THROUGH COURIER SERVICE, WHEN I RECEIVED THIS HERBAL MEDICINE USED IT FOR 2 WEEKS, AND 4 DAYS OF USAGE THE WARTS FELL OFF, MY MOTHER I NOW TOTALLY CURED AND MY MOTHER IS LIVING FREE AND HAPPY AGAIN. YOU CAN TALK TO DR VIA HIS MOBILE NUMBER OR WHATS APP HIM ON if you have any of these diseases lupus disease, mouth ulcer, mouth cancer, body pain, fever, hepatitis ABC, syphilis, diarrhea, HIV / AIDS, Huntington's disease, back acne, chronic kidney failure, addison's disease, chronic pain, Crohn's pain, cystic fibrosis, fibromyalgia, inflammatory Bowel disease, fungal nail disease, Lyme disease, Celiac disease, Lymphoma, Major depression, Malignant melanoma, Mania, Melorheostosis, Meniere's disease, Mucopolysaccharidosis, Multiple sclerosis, Muscular dystrophy, Rheumatoid arthritis Alzheimer's disease, parkinson's disease, vaginal cancer, epilepsy Anxiety Disorders, Autoimmune Disease, Back Pain, Back Sprain, Bipolar Disorder, Brain Tumor, Malignant, Bruxism, Bulimia, Cervical Disc Disease, Cardiovascular Disease, Neoplasms , chronic respiratory disease, mental and behavioral disorder, Cystic Fibrosis, Hypertension, Diabetes, Asthma, Inflammatory Media autoimmune arthritis ed. chronic kidney disease, inflammatory joint disease, impotence, alcohol spectrum feta, dysthymic disorder, eczema, tuberculosis, chronic fatigue syndrome, constipation, inflammatory bowel disease. and many more; +2348152855846.ALL THANKS TO DOCTOR DR JAMES
leonard farell
May 20, 2022 at 3:46 AM

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